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2 edition of Effect of light on the stability of aqueous solution of phenylephrine hydrochloride found in the catalog.

Effect of light on the stability of aqueous solution of phenylephrine hydrochloride

Riadh Abdulla Abdan Altaii

Effect of light on the stability of aqueous solution of phenylephrine hydrochloride

by Riadh Abdulla Abdan Altaii

  • 146 Want to read
  • 27 Currently reading

Published by Leicester Polytechnic in Leicester .
Written in English


Edition Notes

Thesis (M.Phil.) - Leicester Polytechnic, Leicester 1980.

StatementRiadh Abdulla Abdan Altaii.
ContributionsLeicester Polytechnic. School of Pharmacy.
ID Numbers
Open LibraryOL17953269M

Phenylephrine is a nasal decongestant that provides relief from nasal discomfort caused by colds, allergies, and hay fever. It belongs to a class of drugs called vasopressors, and it works by 2/5.   Neo-Synephrine (phenylephrine hydrochloride ophthalmic solution) is a vasoconstrictor (constricts the veins) and mydriatic (dilates the pupils), and the over-the-counter strength is used to relieve redness, burning, irritation, and dryness of the eye caused by wind, sun, and other minor iption-strength Neo-Synephrine is used to constrict blood vessels in the eye and .

Uses. Phenylephrine is used for the temporary relief of stuffy nose, sinus, and ear symptoms caused by the common cold, flu, allergies, or other breathing illnesses (e.g., sinusitis, bronchitis. PHENYLEPHRINE HYDROCHLORIDE SIGMA REFERENCE STANDARD Product No. P Lot K INFRARED SPECTRUM KBr dispersion Wavenumbers (cm-1) 7/ For R&D use only. Not for drug, household or other uses. Sigma brand products are sold through Sigma-Aldrich, Inc.

Phenylephrine is a medication primarily used as a decongestant, to dilate the pupil, to increase blood pressure, and to relieve hemorrhoids. While marketed as a decongestant, taken by mouth at recommended doses it is of unclear benefit for hay fever. It can be taken by mouth, given by injection into a vein or muscle, or applied to the ncy category: US: C (Risk not ruled out). Find patient medical information for Phenylephrine Ophthalmic (Eye) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.


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Effect of light on the stability of aqueous solution of phenylephrine hydrochloride by Riadh Abdulla Abdan Altaii Download PDF EPUB FB2

Phenylephrine hydrochloride (HCl) is commonly used to maintain adequate blood pressure during shock and shocklike states. Phenylephrine is prepared in concentrated stock vials that require further dilution prior to : Josiah J. Jansen, Alan R.

Oldland, Tyree H. Kiser. The chemical stabilities of lignocaine hydrochloride (lidocaine hydrochloride) and phenylephrine hydrochloride in a combination aqueous solution have been determined using stability-indicating high-performance liquid chromatographic methods.

The drugs did not interact and were stable for at least 66 days at room by: 9. Effects of oxygen, visible light, and phosphate on methionine oxidation in aqueous solution and evaluation of possible mechanisms, Pharm.

Res. – PubMed CrossRef Google Scholar Fransson, J.R., Cited by: The chemical stability of phenylephrine hydrochloride ( and mg/mL) in % sodium chloride injection stored in polyvinyl chloride bags was studied at 25 deg C by means of a stability Author: Vishnu Gupta.

The impurities and degradation products of phenylephrine hydrochloride have long been studied. This research work examined the effects of various excipients on solution and solid degradation reactions, with particular emphasis on the formation of covalent adducts with the drug compounds.

Stability of Phenylephrine Hydrochloride and Chlorphenamine Maleate in Solid Preparation. An adduct of phenylephrine and maleic acid could be formed through the reaction of phenylephrine hydrochloride(1) and chlorphenamine maleate(2) in solid preparation.

The influences of temperature(25 and 50 ℃), water content(0 and 10 %), p H. An optically pure specimen of levo-diacetylphenylephrine has been prepared. This substance has served as a basis for subsequent measure of the resistance of l phenylephrine hydrochloride toward racemization when multiple autoclaved, and when refluxed at two pH levels.

The effect of time vs. stereochemical stability, in commercial l-phenylephrine hydrochloride formulas, has likewise been Cited by: 2. Prematurity’s retinopathy is detected by a regular fundus performed during the first weeks of life, using a mydriatric solution.

In the French National Agency for Medicines and Health product Safety expressed a recommendation about the preferential use of phenylephrine % or 1 % and tropicamide rather than atropine.

The chemical stability of phenylephrine hydrochloride ( and mg/mL) in % sodium chloride injection stored in polyvinyl chloride bags was studied at 25 deg C by means of a stability. Another consequence of the Combat Methamphetamine Epidemic Act was the approval of phenylephrine bitartrate (phenylephrine hydrogentartrate) as an active ingredient in OTC cough and cold products in effervescent dosage forms by the FDA in August additionally to phenylephrine ly phenylephrine bitartrate is regarded as a more stable salt compared to the by: 5.

Phenylephrine hydrochloride Drug Entry Phenylephrine. Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, 6,8 dilate the pupil, 7 and induce local vasoconstriction.

1 The action of phenylephrine, or neo-synephrine, was first described in literature in the s. Phenylephrine was granted FDA approval in 7. Phenylephrine Hydrochloride Ophthalmic Solution, % and 10% 2 The NDA does not provide sufficient stability data to establish the stability profile of the drug product over the requested shelf-life.

Per ICH Q1A (R2), month long-term and 6-month accelerated stability data for three batches should be provided for us to be. Phenylephrine Hydrochloride is the hydrochloride salt form of phenylephrine, a direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property.

Phenylephrine is a post-synaptic alpha-adrenergic receptor agonist that causes vasoconstriction, increases systolic/diastolic pressures, reflex bradycardia, and stroke output.

When PCM-T solution was kept in the dark at 37 °C for 2 weeks, no tetracaine was released (Supplementary Fig. 13), indicating good stability in the dark.

Fig. 3: In vitro photocleavage of. Phenylephrine hydrochloride is very soluble in water, freely soluble in ethanol, and insoluble in chloroform and ethyl ether.

Phenylephrine hydrochloride is sensitive to light. Phenylephrine Hydrochloride Injection, USP is a clear, colorless, aqueous solution File Size: KB. - Each 5 ml ampoule of Phenylephrine mg/ml contains phenylephrine hydrochloride equivalent to mg phenylephrine.

- Each 10 ml ampoule of Phenylephrine mg/ml contains phenylephrine hydrochloride equivalent to mg phenylephrine. Excipient with known effect: Each 10 ml ampoule contains 1,6 mmol (36,8 mg) sodium.

Phenylephrine hydrochloride is sensitive to light. Phenylephrine Hydrochloride Injection, USP is a clear, colorless, aqueous solution that is essentially free of visible foreign matter.

Each mL contains: Phenylephrine Hydrochloride 10 mg; Sodium Chloride mg; Sodium Citrate Dihydrate 4 mg; Citric Acid Monohydrate 1 mg; and Sodium Metabisulfite 2 mg in Water for Injection. Physical stability (visual inspection, osmolality measurements), chemical stability (pH measurement, phenylephrine assay by liquid chromatography coupled with an ultra-high resolution and accurate mass) and sterility evaluation of phenylephrine eye drop solution stored at.

Phenylephrine Ophthalmic Solution Dosage and Administration General Dosing Recommendations. In patients 1 year of age or greater, apply one drop of either phenylephrine hydrochloride ophthalmic solution % or 10% every 3 to 5 minutes to the conjunctival fornix as required up to a maximum of 3 drops per eye per day/ It has an adverse effect on intraocular pressure, corneas, conjunctiva and lids.

Trembling and perspiration may occur. Exposure to this compound may cause peripheral vasoconstriction, an increase in arterial pressure, reflex bradycardia and a rise in blood pressure Extravasation of the injection may cause tissue necrosis. Phenylephrine is a member of the class of the class of phenylethanolamines that is (1R)(methylamino)phenylethanol carrying an additional hydroxy substituent at position 3 on the phenyl ring.

It has a role as an alpha-adrenergic agonist, a cardiotonic drug, a mydriatic agent, a protective agent, a vasoconstrictor agent, a sympathomimetic agent and a nasal decongestant.Spectrophotometric Determinaiton of 4- Aminoantipyrine in Aqueous solution by coupling with Diazotised phenylephrine hydrochloride Yousif J.

Azeez, Lana M. Ali 1 Dep. of Chem. College of Science, University of Salahaddin, Erbil, Iraq 2 Dep. of Chem. College of Science, University of Sulaimania, Sulaimania, Iraq.Phenylephrine hydrochloride ophthalmic solution 10% is contraindicated in pediatric patients less than 1 year of age due to the increased risk of systemic toxicity.

Phenylephrine hydrochloride ophthalmic solution % should be used in these patients [See Dosage and Administration ()].